ea0056gp110 | Diabetes Translational | ECE2018
Bielohuby Maximilian
, Raichur Suryaprakash
, Stolte Manuela
, Hemmann Ulrike
, Gorgens Sven W
, Wohlfart Paulus
, Jahn-Hofmann Kerstin
, Brunner Bodo
, Tennagels Norbert
Class 2a HDACs (i.e. HDAC 4, 5, 7 and 9) are involved in the regulation of gluconeogenesis and accordingly, their inhibition has been shown to result in lower blood glucose and improved pyruvate tolerance in diabetic mice. However, pan-inhibition of HDACs is not a viable approach for chronic treatment of type 2 diabetes (T2D) due to induction of severe side effects in various tissues. We now have investigated in vitro and in vivo efficacy and safety of a live...